Search scope:
排序: Display mode:
Vaccine therapies for chronic hepatitis B: can we go further?
Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 17-23 doi: 10.1007/s11684-014-0313-7
Chronic hepatitis B is a major health burden worldwide.progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronichepatitis B.On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitisB patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based
Keywords: chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 135-144 doi: 10.1007/s11684-014-0331-5
Chronic hepatitis B is a major health problem in China.The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infectionThe most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in westernChronic hepatitis B poses a heavy burden to the society in China.
Keywords: chronic hepatitis B epidemiology prevention treatment
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 271-276 doi: 10.1007/s11684-009-0054-1
Keywords: hepatitis B chronic viral load liver cirrhosis
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 111-125 doi: 10.1007/s11684-021-0854-5
Keywords: COVID-19 chronic hepatitis B liver injury coagulation dysfunction
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 129-134 doi: 10.1007/s11684-014-0339-x
Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.mutant becomes predominant in the viral population following elimination of the wild-type virus in duck hepatitisB virus-chronically infected animals.and reinfection, and such cycles prolong the chronic HBV infection course.
Keywords: hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion
Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 250-253 doi: 10.1007/s11684-014-0333-3
The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.Comprehensive treatments included effective inhibition of hepatitis B virus replication and intensive
Keywords: acute-on-chronic liver failure submassive necrosis viral hepatitis B esophageal variceal bleeding liver
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitisIn this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifeIn contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integratedimplicated as a “para-functional cure,” a status nearly close to the functional cure of chronichepatitis B, to distinguish the “functional cure” characterized as serum HBsAg loss with
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 145-157 doi: 10.1007/s11684-014-0335-1
Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than
Keywords: chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines
Advances in newly developing therapy for chronic hepatitis C virus infection
Paul J. Pockros
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 166-174 doi: 10.1007/s11684-014-0334-2
Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and isMorbidity and mortality are decreased with the successful treatment of chronic HCV infection.
Keywords: direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors
MicroRNAs and hepatitis viruses
Gang LI MD , Xiaojia XIONG MM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 265-270 doi: 10.1007/s11684-009-0055-0
Keywords: microRNA hepatitis B virus hepatitis C virus
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leadingtherapy is efficacious in suppressing HBV replication; however, it fails to completely cure patients with chronichepatitis B and even requires lifelong treatment.Work is still needed to eliminate hepatitis B in China by 2030.
Keywords: HBV CHB biomarker functional cure coinfection
Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang
Engineering 2023, Volume 26, Issue 7, Pages 151-158 doi: 10.1016/j.eng.2023.03.008
Keywords: Liver fibrosis Chronic hepatitis B Serum N-glycan N-glycan model Alanine aminotransferase
Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 419-429 doi: 10.1007/s11684-010-0160-0
Keywords: hepatitis B virus hepatocellular carcinoma mutation genotype haplotype
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 217-226 doi: 10.1007/s11684-014-0326-2
Keywords: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 399-411 doi: 10.1007/s11684-010-0170-y
Keywords: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional
Title Author Date Type Operation
Vaccine therapies for chronic hepatitis B: can we go further?
Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan
Journal Article
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Journal Article
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
Journal Article
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center
Journal Article
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Journal Article
Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report
Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang
Journal Article
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Journal Article
Advances in newly developing therapy for chronic hepatitis C virus infection
Paul J. Pockros
Journal Article
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Journal Article
Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic HepatitisB Patients with Normal Alanine Aminotransferase Levels
Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang
Journal Article
Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular
Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,
Journal Article
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitisB virus mutations with hepatocellular carcinoma risk
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Journal Article